Cardiovascular effect of cannabis sativa oil on hypertensive rats

LUISA F GONZÁLEZ ARBELÁEZ; FIORELLA CAVALLI ; ALEJANDRO CIOCCI PARDO ; SUSANA M. MOSCA ; JOSHUA GODOY COTO ; OSWALDO ARANDA ; JORGE OMAR VELEZ RUEDA ; IRENE L ENNIS ; ERICA VANESA PEREYRA; JULIANA C FANTINELLI; JORGE E. COLMAN LERNER ; OSCAR A. PINILLA

Santiago de Chile

Congreso; Congreso Asociación Latinoamericana de Ciencias Fisiológicas; 2020

Asociación Latinoamericana de Ciencias Fisiológicas y Sociedad Chilena de Ciencias Fisiolíogicas

Introduction: Cannabis sativa oil has been used for different medical purposes like pain relief or refractory epilepsy treatment. Its main pharmacological components are Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD, through the endocannabinoid-system receptors (CB1 and CB2) has cardioprotective effects against inflammatory and oxidative damage. However, the effect of Cannabis sativa oil on hypertensive cardiac hypertrophy (CH) remains unclear. In CH dysfunctional mitochondria may produce deleterious effects on heart function.Objective: The aim of this study was to evaluate the activation of the endocannabinoid system attenuates CH and improves myocardial mitochondria function in spontaneously hypertensive rats (SHR).Methods: Three month old male SHR were randomized into treated (TR, n=4) and control (CR, n=4). and Cannabis sativa oil was orally administered for 1 month to TR. We measured CH by weighting and by ultrasound and mitochondrial membrane potential by spectrofluorometry. Data are presented as mean±SEM and Welch?s t-test was used for statistical differences (p