Novel effect of cannabis sativa oil on the myocardium of hypertensive rats

PEREYRA E; FANTINELLI JC; COLMAN LERNER E; PINILLA O; GODOY COTO J; CAVALLI F; CIOCCI PARDO A; MOSCA SM; GONZALEZ ARBELAEZ L; ARANDA O; VELEZ RUEDA O; ENNIS I

Buenos Aires

Congreso; Reunión anual SAFIS; 2020

Cannabis sativa oil has been used for different medical purposes like pain relief or refractory epilepsy treatment. Its main pharmacological components are Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD, through the endocannabinoid-system receptors (CB1 and CB2) has cardioprotective effects against inflammatory and oxidative damage. However, the effect of THC and CBD on hypertensive cardiac hypertrophy (CH) remains unclear. In CH dysfunctional mitochondria may produce deleterious effects on heart function. Thus, we tested the hypothesis that activation of the endocannabinoid system attenuates CH and improves myocardial mitochondria function in spontaneously hypertensive rats (SHR). To this aim, 3-month old male SHR were randomized into treated (TR) (N=4) and control (CR) (N=4). Cannabis sativa oil was orally administered to TR for 1 month. Data are presented as mean±SEM and Welch?s t-test was used for statistical differences (p