ADIPOSE TISSUE'S METABOLIC MODIFICATIONS IN RESPONSE TO AEROBIC TRAINING IN SPONTANEOUSLY HYPERTENSIVE RATS

CAVALLI F; VILLAGARCIA H ; ENNIS IL; COTO GODOY J; YEVES AM; CALDIZ CI; PEREYRA E; FRANCINI F

Buenos Aires

Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2020; 2020

SAFIS

There is an association between hypertension (HT), insulin resistance (IR), and oxidative stress (OE). In previous studies, we have demonstrated the presence of IR and increased EO in spontaneously hypertensive rats (SHR). Also, it is known that physical training delays the progression of vascular disease and improves insulin sensitivity. These effects possibly involve modifications in adipose tissue (AT).Objective: to determine the effects of aerobic training (AE) on IR, OE and AT phenotype in SHR.Materials and methods: SHR were randomly assigned to a sedentary group (S) and another one subjected to a swimming routine for 8 weeks (Ex). Oxidative stress was determined by T-Bars and O2- production measured by the lucigenin method. To study the insulin response, Glut4 expression and phosphorylation were measured in adipocyte membrane fractions and a glucose tolerance curve (GTC) was performed. To determine changes in the phenotype of AT, histological sections were analyzed by light microscopy. Results are expressed as mean ± SE and statistically analyzed by T-test, considering p