APELIN IS A MEDIATOR OF THE MYOCARDIAL ADAPTATIONS INDUCED BY SWIMMING ROUTINE

GODOY COTO, JOSHUA; CALDIZ, CLAUDIA; CAVALLI, FIORELLA; ENNIS, IRENE; YEVES, ALEJANDRA; PEREYRA, ERICA

Buenos Aires

Congreso; Reunión Anual de Sociedades de Biociencias 2020; 2020

SAIC-SAI-SAFIS

Introduction. Apelin is a short-length peptide that increases in response to exercise training in the myocardium of spontaneously hypertensive rats (SHR) improving cardiovascular vasodilation, antioxidant capacity, and mitochondrial function. However, the molecular mechanisms underlying these actions have not been elucidated yet. We hypothesize that aerobic training, through the apelin pathway, may attenuate oxidative stress and mitochondrial structural and functional alterations in the hypertrophied myocardium of the SHR. Aim. To explore whether a swimming routine or the exposure to exogenous apelin produces adaptations in the SHR myocardium. Methods. The experimental group ?SR? performed an 8-week swimming routine and was compared with non-trained group, ?NT?. Results were expressed as mean±SEM and analyzed by Student´s t test or ANOVA, as appropriate (p