AEROBIC TRAINING-INDUCED MITOCHONDRIAL ADAPTATIONS IN HYPERTENSIVE MYOCARDIUM Godoy Coto J1, Yeves AM1, Pereyra EV1, Ennis IL1.

GODOY COTO J.; ENNIS I.L.; PEREYRA E,; YEVES A.M.,

Congreso; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIAS SAIC - SAI - SAFIS 10 AL 13 DE NOVIEMBRE | 2020; 2020

REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIAS SAIC - SAI ? SAFIS.

Pathological cardiac remodeling occurs as a response to essential hypertension and consists of ultrastructural alterations and mitochondrial dysfunction. Physiological cardiac adaptations occur in response to aerobic training to satisfy the work-load during exercise. Despite this, its beneficial effects on the mitochondria have not been completely elucidated in the hypertensive myocardium. This study objective is to determine whether sustained swimming training (8 weeks, 5 days/week) improves myocardial mitochondrial phenotype in spontaneously hypertensive rats (SHR). Our results suggest that aerobic training: improved mitochondrial phenotype through less depolarized ΔΨm, increased mitochondrial Ca+2 and citrate synthase activity; improved the mitochondrial-sarcomere array; and promoted a dysfunctional mitochondrial clearance process -reduced fusion and enhanced biogenesis, fission, and mitophagy. Taken together, these results clarify that exercise induces beneficial adaptations not only in the heart as an organ but also specifically in the cardiac mitochondria.