CIC   05421
CENTRO DE INVESTIGACIONES CARDIOVASCULARES "DR. HORACIO EUGENIO CINGOLANI"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Na+/H+ exchanger localization in ventricular myocytes membranes
Autor/es:
ZAVALA MR, ; GODOY COTO J, ; ESPEJO MS,; DE GIUSTI VC, ; MATÉ SM, ; VILLA-ABRILLE MC
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017
Resumen:
The Na+/H + exchanger (NHE1), an integral membrane protein, is involved in the maintenance of the intracellular pH (pHi). Its activity is regulated by allosteric site sensitivity for H+, phosphorylation and by the union of ATP, lipids, growth factors in its cytoplasmic tail. The objective of the present work was to evaluate a putative role of certain membrane domains, such as caveolae, in the modulation of NHE1 activity. In isolated myocytes from normotensive rats (SP: 118.8 ± 6.2 mmHg) and SHR (SP: 182.5 ± 15.5 mmHg, p