P38 MAP KINASE (P38) NEGATIVELY REGULATES THE SLOW FORCE RESPONSE (SFR) TO MYOCARDIAL STRETCH

DIAZ, RG; PEREZ, NG; ZAVALA M; CINGOLANI HE; ENNIS, IL.; VILLA-ABRILLE MC,

Congreso; PANAM - 1st PanAmerican Congress of Physiological Sciences; 2014

[Abstract ID: 450] PÔSTER P38 MAP KINASE (P38) NEGATIVELY REGULATES THE SLOW FORCE RESPONSE (SFR) TO MYOCARDIAL STRETCH NÉSTOR GUSTAVO PÉREZ1; ROMINA GISEL DIAZ1; MAITE ZAVALA1; IRENE LUCIA ZAVALA1; HORACIO EUGENIO CINGOLANI1; MARÍA CELESTE VILLA ABRILLE1. 1.CENTRO INVESTIGACIONES CARDIOVASCULARES, LA PLATA - ARGENTINA. Abstract The SFR is the mechanical counterpart of a stretch-triggered autocrine mechanism that involves the release of angiotensin II/endothelin leading to the redox sensitive NHE1 phosphorylation/activation. Since p38 inhibition strengthens the angiotensin II-induced NHE1 activation in vascular smooth muscle, we hypothesized that it should modulate the SFR in the myocardium. In isolated rat papillary muscles the SFR was significantly increased by p38 inhibition with 10μmol/L SB202190, (27±2 vs 17±2 % of initial rapid phase, n=6, p