CIC   05421
CENTRO DE INVESTIGACIONES CARDIOVASCULARES "DR. HORACIO EUGENIO CINGOLANI"
Unidad Ejecutora - UE
capítulos de libros
Título:
EARLY INTRACELLULAR SIGNALS AFTER MYOCARDIAL STRETCH LEADING TO CARDIAC HYPERTROPHY. KEY ROLE OF NHE-1.
Autor/es:
CINGOLANI HE,; PÉREZ NG,; AIELLO EA,; ENNIS IL,; GARCIARENA CD,; VILLA-ABRILLE MC,; DULCE RA,; CALDIZ CI,; YEVES AM,; CORREA MV,; NOLLY MB,; CHIAPPE DE CINGOLANI GE
Libro:
Special issue Calcium and the Heart: Signaling and Regulation of the Encyclopedia of Bioscience
Referencias:
Año: 2008; p. 7096 - 7116
Resumen:
ABSTRACTThe enhanced activity of the cardiac Na+/H+exchanger (NHE-1) after myocardial stretch is considered akey step of the intracellular signaling pathway leading to theslow force response to stretch as well as an early signal forthe development of cardiac hypertrophy. We propose thatthe chain of events triggered by stretch begins with therelease of small amounts of Angiotensin II (AngII)/endothelin (ET) and ends with the increase inintracellular Ca2+ concentration ([Ca2+]i) through theNa+/Ca2+ exchanger in reverse mode (NCXrev), whichtriggers cardiac hypertrophy by activation of widelyrecognized Ca2+-dependent intracellular signaling pathways.increase in contractility induced by Ca2+ influx.Furthermore, we have proposed that an enhanced activationof NHE-1 is a key factor in this signaling pathway byincreasing intracellular Na+ concentration ([Na+]i), whichdrives the NCXrev thus increasing Ca2+ transient andcontractility. The question as to why this mechanismshould be connected to the development of myocardialhypertrophy appears to be answered by the fact that anenhanced activity of NHE-1 is detected in several modelsof cardiac hypertrophy where specific NHE-1 blockaderegresses cardiac hypertrophy effectively.