Early activation of intracellular signals after myocardial stretch: Anrep effect, myocardial hypertrophy and heart failure

CINGOLANI HE,; VILLA-ABRILLE MC; CALDIZ CI; ENNIS IL; CINGOLANI OH; MORGAN PE; AIELLO EA; PÉREZ NG

Mechanically Gated Channels and their Regulation. Mechanosensitivity in Cells and Tissues

Springer

Lugar: Moscú; Año: 2012; p. 327 - 365

The link between the Anrep effect -the increase in cardiac contractility that develops 10-15 min following myocardial stretch- and myocardial hypertrophy and failure was not appreciated until we proposed it in the 2005 edition of the book ?Mechanosensitivity in Cells and Tissues?. In this new version of the chapter we will present the updated experimental evidence that led us to propose the autocrine/paracrine mechanism underlying the Anrep effect, as well as its resemblance to signals that have been described for cardiac hypertrophy development and heart failure. Interesting novel data supporting a crucial role for stretch-induced mineralocorticoid receptor activation, EGFR transactivation and increased mitochondrial production of reactive oxygen species leading to NHE-1 stimulation will be thoroughly described. A clear understanding of the early triggering mechanisms that stretch imposes to the myocardium will allow us to design novel weapons to win the battle against cardiac hypertrophy and failure, a major disease spread worldwide.