CIC 05421
CENTRO DE INVESTIGACIONES CARDIOVASCULARES "DR. HORACIO EUGENIO CINGOLANI"
Unidad Ejecutora - UE
artículos
Título:
Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1.
Autor/es:
CINGOLANI HE; PEREZ NG; AIELLO EA; ENNIS IL; GARCIARENA CD; VILLA-ABRILLE MCM; DULCE RA; CALDIZ CI; YEVEZ MA; CORREA MV; NOLLY MB; CHIAPPE DE CINGOLANI GE
Revista:
Frontiers in Bioscience
Editorial:
Frontiers In Bioscience Publications
Referencias:
Año: 2008 vol. 13 p. 7096 - 7114
ISSN:
1093-4715
Resumen:
The enhanced activity of the cardiac Na+/H+exchanger (NHE-1) after myocardial stretch is considered akey step of the intracellular signaling pathway leading to theslow force response to stretch as well as an early signal forthe development of cardiac hypertrophy. We propose thatthe chain of events triggered by stretch begins with therelease of small amounts of Angiotensin II (AngII)/endothelin (ET) and ends with the increase inintracellular Ca2+ concentration ([Ca2+]i) through theNa+/Ca2+ exchanger in reverse mode (NCXrev), whichtriggers cardiac hypertrophy by activation of widelyrecognized Ca2+-dependent intracellular signaling pathways.
