CENTRO DE INVESTIGACIONES CARDIOVASCULARES "DR. HORACIO EUGENIO CINGOLANI"
Unidad Ejecutora - UE
Na+/H+ exchanger, cardiac overload and myocardial hypertrophy.
CINGOLANI HE; ENNIS IL
Año: 2007 vol. 115 p. 1090 - 1100
Overload of neonatal and adult cardiomyocytes, and multicellular myocardial preparations, including whole hearts, is accompanied by an enhanced activity of the Na+/H+ exchanger 1 (NHE-1). Exogenous administration of prohypertrophic agents such as angiotensin II, endothelin-1 and a1-adrenergic agonists also stimulates NHE-1 activity, leading to an increased concentration of intracellular Na+ ([Na+]i). Moreover, inhibition of NHE-1 activity prevents the increase in [Na+]i, induces the regression of cardiac hypertrophy and exerts beneficial effects in experimental heart failure. This present review summarizes the current knowledge of the causative factors and pathophysiological correlation of cardiac overload and NHE-1 activity.