CIC 05421
CENTRO DE INVESTIGACIONES CARDIOVASCULARES "DR. HORACIO EUGENIO CINGOLANI"
Unidad Ejecutora - UE
artículos
Título:
Na+/H+ exchanger, cardiac overload and myocardial hypertrophy.
Autor/es:
CINGOLANI HE; ENNIS IL
Revista:
CIRCULATION
Referencias:
Año: 2007 vol. 115 p. 1090 - 1100
ISSN:
0009-7322
Resumen:
Overload of
neonatal and adult cardiomyocytes, and multicellular myocardial preparations,
including whole hearts, is accompanied by an enhanced activity of the Na+/H+
exchanger 1 (NHE-1). Exogenous administration of prohypertrophic agents such as
angiotensin II, endothelin-1 and a1-adrenergic
agonists also stimulates NHE-1 activity, leading to an increased concentration
of intracellular Na+ ([Na+]i). Moreover,
inhibition of NHE-1 activity prevents the increase in [Na+]i,
induces the regression of cardiac hypertrophy and exerts beneficial effects in
experimental heart failure.
This present review summarizes the current
knowledge of the causative factors and pathophysiological correlation of
cardiac overload and NHE-1 activity.
