CENTRO DE INVESTIGACIONES CARDIOVASCULARES "DR. HORACIO EUGENIO CINGOLANI"
Unidad Ejecutora - UE
Gender differences in cardiac left ventricular mass and function: clinical and experimental observations
ESCUDERO EM; ORLOWSKI A; DIAZ A; PINILLA OA; ENNIS IL; AIELLO EA
Año: 2014 p. 53 - 59
Objective: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and function (LVF) in humans and rats with aging. Methods: Myocytes area and collagen volume fraction (CVF) were studied in rats. LVM and LVF were evaluated in animals and humans by echocardiography and LVM index (LVMI) were obtained. Results: LVMI, myocytes area and CVF were similar in male and female 1 month old rats. LVMI in children was similar in both genders. In contrast, in the 6 months old rats (5 male and 5 female), LVMI (17.7±0.7mg/mm vs 10.1±0.2mg/mm;p<0.01), and myocytes area (4572.5±72.6μm2 vs 3293.85±57.8μm2,p<0.01) were higher in male animals, without differences in CVF. Men (n=25) exhibited greater LVMI than women (n=25) (77.4±3.2g/m2 vs 63.3±1.8g/m2,p<0.01), while the LVF was higher in women (105.9±2.9% vs 95.3±3.5%, p<0.01). Conclusion: There is a clear gender-associated impact on LVM with aging in humans and rats. The similar CVF and LVF associated to the greater myocytes size and LVM in male rats suggests a process of physiological response. However, the increase in cardiac mass without an associated improved cardiac function in men in comparison to women could likely represent a potential disadvantage in the adaptive response during growth.