CENTRO DE INVESTIGACIONES CARDIOVASCULARES "DR. HORACIO EUGENIO CINGOLANI"
Unidad Ejecutora - UE
Gender differences in cardiac left ventricular mass and function: clinical and experimental observations.
ESCUDERO EM, ORLOVSKY A, DIAZ A, PINILLA OA, ENNIS IL
Lugar: Cracovia; Año: 2014 vol. 21 p. 53 - 59
OBJECTIVE: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and function (LVF) in humans and rats with aging. METHODS: Myocytes area and collagen volume fraction (CVF) were studied in rats. LVM and LVF were evaluated in animals and humans by echocardiography and LVM index (LVMI) were obtained. RESULTS: LVMI, myocytes area and CVF were similar in male and female of 1monthold rats. LVMI in children was similar in both genders. In contrast, in 6-month-old rats (5 male and 5 female), LVMI (17.7±0.7mg/mm vs. 10.1±0.2mg/mm;p<0.01), and myocytes area (4572.5±72.6ìm² vs. 3293.85±57.8ìm²,p<0.01) were higher in male animals, without differences in CVF. Men (n=25) exhibited greater LVMI than women (n=25) (77.4±3.2g/m² vs. 63.3±1.8g/m²,p<0.01), whereas the LVF was higher in women (105.9±2.9% vs. 95.3±3.5%, p<0.01). CONCLUSIONS: There is a clear gender-associated impact on LVM with aging in humans and rats. Similar CVF and LVF associated to greater myocytes size and LVM in male rats suggest a process of physiological response. However, the increase in cardiac mass without an associated improved cardiac function in men in comparison to women could likely represent a potential disadvantage in the adaptive response during growth.