CIC 05421
CENTRO DE INVESTIGACIONES CARDIOVASCULARES "DR. HORACIO EUGENIO CINGOLANI"
Unidad Ejecutora - UE
artículos
Título:
A possible subcelular mechanism underlying the French Paradox: The opening of mitochondrial KATP channels
Autor/es:
AIELLO EA; CINGOLANI HE
Revista:
Applied Physiology, Nutrition, and Metabolism
Editorial:
NRC Research Press
Referencias:
Año: 2011 vol. 36 p. 768 - 772
ISSN:
1715 5312
Resumen:
A reduction in the risk of coronary heart disease has been associated to moderate red wine consumption. We tested whether a nonalcoholic red wine extract would open mitochondrial K(ATP) channels in guinea pig myocytes. The opening of mitochondrial K(ATP) channels was assessed by endogenous flavoprotein fluorescence. Red wine extract (100 ìg·mL(-1)) increased flavoprotein oxidation (10.9% ± 1.2%, n = 20). This effect was prevented by the mitochondrial K(ATP) channel blocker, 5-hydroxydecanoate (500 µmol·L(-1); 0.3% ± 1.1%, n = 13), confirming the hypothesis that red wine extract opens mitochondrial K(ATP) channels.
