CEPAVE 05420
CENTRO DE ESTUDIOS PARASITOLOGICOS Y DE VECTORES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Biophysical studies of Triatoma virus (TrV)
Autor/es:
AGIRRE, J; SANCHEZ, E; NEUMANN, E; MARTI, G. A.; ALORIA, K; ARIZMENDI, J, M; DE PABLO, P, J; GUERIN, D.M.A.
Lugar:
Lisboa, Portugal
Reunión:
Workshop; I Iberoamerican Workshop on Chagas Disease, Triatomine vectors, T. cruzi, and Triatoma virus; 2010
Institución organizadora:
Centro de Malária e Outras Doenças Tropicais (UCDT/CMDT) Instituto de Higiene e Medicina Tropical
Resumen:
Triatoma Virus (TrV) is a spherical,
non-enveloped, +ssRNA virus that infects the triatomine bug Triatoma infestans. TrV belongs to the Dicistroviridae family, but due to its
physico-chemical properties it was formerly classified as an Insect
Picorna-like virus. This virus has been postulated as potential control agent
against Triatoma infestans, one of
themain vectors forChagas Disease in Latin America. Besides its biotechnological
interest, TrV can be a useful model to study molecular mechanisms associated
with non-enveloped virus cell recognition, insertion, disassembly, inmune
response evasion andcapsid assembly. In this work we present the results from
the application of a set of biophysical techniques, which give insights to
several aspects of TrVcapsid organization, stability and disassembly process.
