CEPAVE   05420
CENTRO DE ESTUDIOS PARASITOLOGICOS Y DE VECTORES
Unidad Ejecutora - UE
artículos
Título:
Genomic and phylogenetic analysis of Argentinian Equid Herpesvirus 1 strains
Autor/es:
MARTIN OCAMPOS, G.P; FUENTEALBA; JONES, E.L.R.,; CIGLIANO, M.M.; BARBEITO, C.G; GALOSI, E.C.M.
Revista:
VIRUS GENES
Referencias:
Año: 2008 vol. 38 p. 113 - 117
ISSN:
0920-8569
Resumen:
Abstract Equid Herpesvirus 1 (EHV-1) has long been
causally implicated in the occurrence of abortion, neonatal
death, respiratory disease, and neurological disorders in
horses. This study analyzed for the first time the characteristics
of the genomic section of Argentinian EHV-1
strains and reconstructed the phylogeny in order to establish
their origin. The phylogenetic dataset included 22
Argentinian strains and four additional reference strains
isolated in other countries. The intergenic region between
ORF 62 and ORF 63 was amplified by PCR and sequenced.
The phylogenetic analysis carried out by parsimony algorithms
showed that six of the Argentinian strains had the
same origin as British and Japanese strains. The mapping
of symptoms caused by EHV-1 suggested that neonatal
disease developed through convergent evolution, which
would constitute an adaptation mechanism of the virus.
This study constitutes the first analysis carried out in
South-American strains that establishes the phylogenetic
relationship between Argentinian strains and rebuilds the
evolutionary history of symptoms. This study focuses on a
very important aspect of evolution of HerpesviridaeEquid Herpesvirus 1 (EHV-1) has long been
causally implicated in the occurrence of abortion, neonatal
death, respiratory disease, and neurological disorders in
horses. This study analyzed for the first time the characteristics
of the genomic section of Argentinian EHV-1
strains and reconstructed the phylogeny in order to establish
their origin. The phylogenetic dataset included 22
Argentinian strains and four additional reference strains
isolated in other countries. The intergenic region between
ORF 62 and ORF 63 was amplified by PCR and sequenced.
The phylogenetic analysis carried out by parsimony algorithms
showed that six of the Argentinian strains had the
same origin as British and Japanese strains. The mapping
of symptoms caused by EHV-1 suggested that neonatal
disease developed through convergent evolution, which
would constitute an adaptation mechanism of the virus.
This study constitutes the first analysis carried out in
South-American strains that establishes the phylogenetic
relationship between Argentinian strains and rebuilds the
evolutionary history of symptoms. This study focuses on a
very important aspect of evolution of HerpesviridaeHerpesviridae
infecting perissodactyls and attempts to shed light on the
evolution of symptoms, an issue of high clinical interest.