CENEXA   05419
CENTRO DE ENDOCRINOLOGIA EXPERIMENTAL Y APLICADA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
In vivo and in vitro inhibitory effect of Dexamethasone on the thermogenic process of beige adipocytes
Autor/es:
ZUBIRIA GUILLERMINA; REY AMANDA; GAMBARO SABRINA ELIANA; SPINEDI, EDUARDO; GIORDANO ALEJANDRA; MARTIN FLORENCIA; GIOVAMBATTISTA , ANDRÉS
Lugar:
Mar del Plata
Reunión:
Congreso; LXIII Reunión Anual SAIC; 2018
Institución organizadora:
SAIC
Resumen:
Glucocorticoids (GCs) modulate the biology and function of white and brown adipose tissue (AT); however, GCs effect on beige adipocytes activation remains unknown. We studied dexamethasone (DXM) effects on the thermogenic activity of beige adipocytes from Retroperitoneal AT (RPAT). Male rats were divided into four groups: control (CTR) and DXM injected (sc 0,03mg/Kg/d for 7 days, DXM) and housed at room temperature, and CTR and DXM housed under cold stimulus (4°C for 7 days, CTR-C and DXM-C, respectively). RPAT pads were dissected, weighted and processed for UCP-1 and PGC1⍺ quantification (RT-PCR). Both, DXM and cold exposure decreased RPAT mass/100 gr body weight (P