Cytotoxicity and oxidative stress induced by a complex of Cu(II)-valsartan in osteoblast cell lines

DI VIRGILIO AM, WILLIAMS PAM, REIGOSA MA, BUTENKO N, CAVACO I, ETCHEVERRY, SB.

Puerto Madryn, Chubut. República Argentina.

Otro; SAIB. 46 th Annual Meeting Argentine Society for Biochemistry and Molecular Biology.; 2010

Introduction As part of a project devoted to the investigation of the potential pharmacological properties of metal based drugs, a variety of copper compounds have been synthesized so far in an effort to optimize the pharmacological activity of this metal. Cu(II) exerts essential functions in bone and connective tissue and in the control of inflammatory processes underlying different illnesses (cancer, hypertension,  etc). It participates in different electron transfer reactions as cofactor of numerous enzymatic pathways. The complexation of metals with pharmacological compounds favors the use of lower doses by synergism of their pharmacological properties. Herein, we report the effects of a complex of Cu(II) with the antihypertensive valsartan (Cu-val) in two osteoblastic cell lines (MC3T3-E1 and UMR106), focusing the attention on its cytotoxicity trying and its mechanisms of action. This complex has been sinthetized by us and it has been characterized by different physicochemical methods (CD Abstracts XXVIII Congreso Argentino de Química y 4to. Workshop  de Química Medicinal). The aim of this work was to investigate the potential antitumoral effect of Cu-val in order to offer a new candidate compound to be further tested as a different alternative for tumor chemotherapy.