Antioxidant activity and spectroscopic investigations on ghe mechanism of interaction of methimazol-copper(II) bioactive species with bovine serum albumin

EG FERRER, NM URQUIZA, SG MANCA, L LEZAMA, T ROJO, LG NASO, PAM WILLIAMS.

Tucson. Arizona. USA.

Simposio; BioMetals 2010.; 2010

Several copper complexes have been shown to possess anticancer, anticarcinogenic, and antimutagenic effects both in vitro and in vivo. In particular, in tumoral cells, the SOD activity is lower than in normal cells and as a consequence a variety of copper complexes presenting SOD-like activity were examined for anticancer treatments. Drastic lowering of the SOD activity in erythrocytes has also been reported during methimazole administration in patients with Grave's disease [1].