Anticancer activity of novel copper(II) compound with a Schiff-base on 2D and 3D breast cancer cell models

BALSA, L.M.; LEON I.E; GONZALES BARO AG; FERRARESI V

Mar del Plata

Congreso; LXIII Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica, LXII Reunión Anual de la Sociedad Argentina de Inmunologia (SAIC-SAI-SAFIS); 2019

The development of copper complex has shown to be very potential as antitumor agents. Several findings provide evidence that copper ions are capable of interacting directly with proteins and DNA, causing site-specific damage. We attempt to evaluate the biological activity of a novel copper with a Schiff-base complex against human cancer cell lines: HT29 (colon), MG-63 (osteosarcoma), A549 (lung), MDA-MB-231 (breast) and MCF7 (breast) and one non tumoral cell line L929 (mouse fibroblast), using MTT assay. The complex significantly reduced the cell viability in all cell lines tested (HT29 IC50: 9.71µM; MG-63 IC50: 6.63µM; A549 IC50: 2.82µM; MDA-MB-231 IC50: 1.56µM; MCF7 IC50: 1.70µM; L929 IC50: 4.23µM) (p