Transition metal complexes with 6-methoxyquinoline as antitumor agents. Biological studies on two and three-dimensional cell cultured models

CRISTIAN VILLA PÉREZ; GLORIA CRISTINA VALENCIA URIBE; ETCHEVERRY, S.B.; CADAVID-VARGAS, J.F.; IGNACIO ESTEBAN LEÓN; ANA LAURA DI VIRGILIO; MARÍA CAROLINA RUÍZ ; SORIA, D.B.

Mar del Plata

Congreso; LXI Reunión Anual De La Sociedad Argentina De Investigación Clínica (SAIC); 2016

Sociedad Argentina De Investigación Clínica

Coordination complexes have been extensively studied asantitumor agents, offering a potential alternative for cancer treatment.Both, the ligand and the metal play an important role in thepharmacological properties of the complex. This study evaluatesthe effect of 6-methoxyquinoline complexes with copper, zinc andsilver as antitumor agents in 2D (monolayer) and a 3D (multicellularspheroids) models derived from A549 and MG-63 cell lines.Ag, Cu and Zn complexes significantly reduced the cell viability(P