Platinum(II) complexes based on hidroxyquinoline ligands. Antitumor effects in 2D and 3D human osteosarcoma models.

LEON I.E; MARTIN-SANTOS C.; CADAVID-VARGAS J.F; ALEMAN J; NAVARRO RANNINGER C; ETCHEVERRY S.B

Beijing

Conferencia; 17th International Conference on Biological Inorganic Chemistry (ICBIC17),; 2015

Despite the remarkable success of CDDP (cisplatin)1 in the treatment of different types of cancers, two major limitations of the drug are remarkable (i) its dose-limiting effects and (ii) its inactivity against some of the most frequent human tumor types (e.g. colon and lung cancers). These limitations early stressed the necessity for the search of structural analogues endowed with fewer side effects and capable of overcoming acquired resistance to CDDP. On the other hand, the hydroxyquinolines derivatives have medicinal properties (antineurodegenerative, anticancer activities, etc). Regarding the anticancer activity of the hydroxyquinolines, different mechanisms of action have been reported 2. In this project we report the biological effects of two complexes of platinum(II) with analogous of clioquinol on a 2D (monolayer) and 3D (spheroids) human osteosarcoma cell line MG-63. Based on the results of cytotoxic assays in monolayer (2D) it was observed that after 6 h complex 2 caused a cell viability inhibition at 10-100 µM while 1 did not show any effects in the same range of concentrations (p