CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
congresos y reuniones científicas
NOVEL ANTI-DEPRESSANT ACTIVITY IN ANIMAL MODEL OF ZN(II)-S-METHYL-CYSTEINE COMPLEX AND OTHER PHARMACOLOGICAL ACTIVITIES.
NAHUEL MARESCA; GRACIELA ESCUDERO DE LAINO; E.G. FERRER; P.A.M. WILLIAMS
Rio de Janeiro
Congreso; 5° SIMPOSIO LATINOAMERICANO DE QUÍMICA DE COORDINACIÓN Y ORGANOMETÁLICA ? (5o SILQCOM); 2015
The antidepressant-like effect of simple Zn(II) salts has been proved in several animal models of depression1. In this study, a coordination metal complex of Zn(II) having a sulfur containing ligand is tested as antidepressant for the first time. Treatment of Zn(S-Met)2 (S-Met= S-methyl-L-cysteine) in the rat forced swimming test model of depression shows a decrease in the immobility and an increase in the swimming behavior being this action more effective and remarkable than ZnCl2 (synergic effect as a result of the coordination). There is a great scientific attention in new pharmacological compounds proficient in inhibiting phosphatases activities2 and also acting as antioxidant compounds. The interest in the determination of the antioxidant activity of S-methyl-L-cysteine was based on previous data that indicated the decrease in oxidative stress under the presence of cysteine-containing agents.3 In addition, this work includes the determination of the antioxidant activity and the inhibition studies on acid phosphatase enzyme (AcP). Both S-methyl-L-cysteine and the Zn(S-Met)2 complex have been tested against peroxyl and hydroxyl radicals. The results present evidence of attenuation of hydroxyl but not peroxyl activity. S-methyl-L-cysteine do not produces effect on AcP activity in contrast to the Zn(S-Met)2 complex that behaves as a good inhibitor agent. Finally, bioavailability studies have been performed using fluorescence spectroscopy and the ability of albumin to transport the complex can be determined.