CEQUINOR   05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Essential dynamics of cold denaturation proteins: Model frataxin Yfh1
Autor/es:
YANIS RICARDO ESPINOSA SILVA, RAUL GRIGERA; ERNESTO CAFFARENA
Lugar:
Bahía Blanca
Reunión:
Congreso; VI Argentinian Conference on Bioinformatics and Computational Biology; 2015
Resumen:
The transition from folding to unfolding on decreasing the temperature, is a property of globular proteins that have been considered in the literature, however the explanation of the process is still on debate. A sensible explanation is the approach from Gibbs-Helmholtz equation considering the diminishing of hydrophobic interaction, and then, allowing the hydration of non-polar groups at low temperature . Due to the drastically changes of the protein structure to avoid freezing, any possible experimental data obtained may not describe appropriated a possible extrapolation to the protein native state. We have chosen as alternative approach the simulation using molecular dynamics, analyzing the protein motions by essential dynamics.
rds']