Antitumoral effects of naringenin and its complex with oxidovanadium(IV) on breast cancer cell in culture. Albumin binding studies by Fluorescence Spectroscopy.

LUCIANA G. NASO; MARÍA SOLEDAD ISLAS; MARÍA VALCARCEL; CLARISA SALADO; MERITXELL ROURA-FERRER; EVELINA G. FERRER; PATRICIA A.M. WILLIAMS

Chascomús

Encuentro; LABIC 2014; 2014

INTECH

Fruit and vegetable intake is associated with a reduced risk of cancer and cardiovascular disease. While these protective effects have been primarily attributed to beta-carotene and ascorbate, phenolic constituents may also play a rol . Among the various types of flavonoids, naringenin (4?,5,7-trihidroxyflavanone), found especially en many fruits, has been shown to posees antioxidant, anti-inflamatory, antiproliferative and antimutagenic properties, and recent studies suggest that it could be a useful chemoprotective agent . Taking into account that the breast cancer is the predominant type of cancer in industrialized countries and the second leading cause of cancer-related deaths in women , it is important to focus our studies toward to search of compounds with high selectivity against tumor cells but cause minimal side effects. On the other hand, it is well known that serum albumin is the most important transport protein in plasma and is also capable of binding and transporting metabolites, drugs, dyes and organic compounds. This protein often increases the apparent solubility of hydrophobic drugs in plasma and modulates the circulation, metabolism and effectiveness of many drugs both in vivo and in vitro. It has been also demonstrated that protein?ligand interactions play an important role in a variety of biological processes. The investigation of compounds with respect to their binding to albumin becomes important because of the pharmacokinetic and pharmacodynamic role of such binding .