CEQUINOR   05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Oxidovanadium(IV) complexes with flavonoids. Anticancer activity and mechanisms of action in a human colon adenocarcinomamodel: role of activation of nfkband apoptosis
Autor/es:
LEÓN IE; MUGLIA CI; PORRO V; TISCORNIA,I; BOLLATI-FOGOLÍN M; ETCHEVERRY SB
Lugar:
La Plata
Reunión:
Jornada; IV Jornadas de Química Inorgánica Prof. Dr. Pedro J. Aymonino.; 2014
Institución organizadora:
Centro de Química Inorgánica Prof. Dr. Pedro J. Aymonino - CEQUINOR
Resumen:
The family of polyphenolic flavonoids presents anti-inflammatory and anti-tumor effects. In particular, Chrysin and Silibinin are interesting members of this family, with potent anti-proliferative and anti-metastatic effects against various malignant cell lines. Oxidovanadium(IV) complexes show interesting pharmacological activity mainly as insulin enhancers, osteogenic and anti-tumor agents. In this work we report the biological effects of two complexes of vanadyl(IV) with Chrysin and Silibinin on a human colon adenocarcinoma cell line (HT-29 ATCC HTB 38). VOsil caused an inhibitory effect on cell viability in the range of 75-100 µM while VOchrys only provoked this effect at 100 µM (p
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