CEQUINOR   05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Antitumoral, Antihypertensive, Antimicrobial, and Antioxidant Effects of an Octanuclear Copper(II)-Telmisartan Complex with an Hydrophobic Nanometer Hole
Autor/es:
ISLAS, MARÍA SOLEDAD; MARTÍNEZ MEDINA, J J; LOPEZ TEVEZ, L.; ROJO,T; L LEZAMA; GRIERA MERINO, MERCEDES; CALLEROS, LAURA; CORTES, MARÍA ALICIA; RODRIGUEZ PUYOL, MANUEL; GUSTAVO A. ECHEVERRÍA; PIRO, OSCAR; E.G. FERRER; WILLIAMS P.A.M.
Lugar:
Chascomús
Reunión:
Simposio; IV Latin American Meeting on Biologal Inorganic Chemistry- V WOQUIBIO (Workshop de Química Bioinorgánica); 2014
Resumen:
The
octapeptide Angiotensin II (AII) is a physiologically active major substance of
the renin-angiotensin system (RAS) that causes muscles to contract, producing
hypertension. Sartans are drugs of design that inhibit the RAS AT1 receptor
blockers (ARBs) then inhibiting the vasoconstrictor effects of AII.1
Telmisartan displayed a highly selective and potent antagonism of the AT1
receptor in many tissues. Copper is an essential element for cellular
respiration, iron homeostasis, pigment formation, neurotransmitter production,
connective tissue biosynthesis, and antioxidant defense. It is interesting to
note that the complexation of ARBs with some transition metals could be a
useful strategy to develop novel antihypertensive drugs with enhanced biological
properties. In this communication we report the synthesis and structural
characterization of a new coordination complex of copper(II) and telmisartan,
its antihypertensive, cytotoxic, antibacterial and antifungal effects.