Oxidovanadium(IV) Complexes with Flavonoids: activation of nfkb and apoptosis in HT-29 cell line

LEÓN, IE; PORRO,V; TISCORNIA,I; DI VIRGILIO, AL; BOLLATI-FOGOLIN, M; ETCHEVERRY, SB

Buenos Aires

Congreso; XLVIV Reunión Anual de la Sociedad de Bioquímica y Biología Molecular (Molecular mechanisms in cell signaling and gene expresión, SAIB 2013; 2013

SAIB

Polyphenolic flavonoids present anti-inflammatory and anti-tumor effects. In particular, Chrysin and Silibinin exhibit anti-proliferative and anti-metastatic effects against various malignant cell lines.   In this work we report the biological effects of two complexes of vanadyl(IV) with Chrysin and Silibinin on a human colon adenocarcinoma cell line (HT-29 ATCC HTB 38). VOsil caused an inhibitory effect on cell viability in the range of 75-100 µM while VOchrys only provoked this effect at 100 µM (p