CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
congresos y reuniones científicas
New heteroleptic copper complexes with saccharinate and their cytotoxicity against osteoblast and osteosarcome cell lines
SANTI E, LEÓN I.E, BARAN E.J., ETCHEVERRY S.B, TORRE M.H
Punta del Este
Congreso; 12th International Symposium on Metal Ions in Biology and Medicine; 2013
With the aim of providing efficacious and safe products, the pharmaceutical industry needs to incorporate different substances to maintain their attributes and stability, to aid in the administration and to impede the contamination. Usually, these compounds can form complexes with metals coming from the pharmaceutical formulations or food. Saccharin (sac) is an important sweetening agent used in pharmaceutical vehicles, foods, beverages and in diets for diabetics. Besides, it has three potential coordinating centers: the heterocyclic nitrogen and the carbonyl and sulphonyl oxygen atoms. On the other hand, aminoacids (aa) are ligands that usually transport metals in blood. For this reason it is interesting to study the interaction of essential cations with saccharin and aminoacids. As a part of our work in the development of metal complexes with pharmacological activities or pharmacotechnical interest1, in this work we report the synthesis and characterization (elemental analysis, UV-Vis, IR and Raman spectroscopies) of new mixed Cu(II) complexes with saccharin and aminoacids (gly, ser, gln, asp) with general formula Na2[Cu(sac)2(aa)2]?nH2O. The aminoacids coordinated as bidentate ligands through the amino and carboxylate groups and the sacharinate as monodentate through the heterocyclic nitrogen. Besides, due to the antecedents that several coadjuvants showed biological adverse effect, the antiproliferative activity against osteoblastic cells (MC3T3-E1) and human osteosarcoma cells (MG-63) for [Cu(sac)2(H2O)4]?2H2O (Cu-sac) and Na2[Cu(sac)2(gln)2]?H2O (Cu-sac-gln) were tested. The results presented in the Figure showed that the first complex is less cytotoxic than the second one in both cell lines, showing the importance of these mixed complexes.