Novel Biomaterial Useful for several Medical Purposes.Production and Characterization

G. RUDERMAN; I.G. MOGILNER; E.J. TOLOSA; N. MASSA; M. GARAVAGLIA; J.R. GRIGERA

Montevideo, Uruguay

Congreso; International Conference of Biological Physics and 5th Southern Cone Biophysics Congress; 2007

International Union of Pure and Applied Physics (IUPAP)

 A novel biomaterial made of collagen, that would presumably be useful in repairing hypertrophic injuries and cheloides is presented. This material is a membrane made of the protein, ordered at a molecular level. Collagen is a highly occurring protein in several body tissues and the molecule has a cylindrical geometry. It  first arranges in fibrils, then into fibers, to finally conform very ordered aggregates like the skin. Each aggregate posses its own pattern, according to the relevant function. Collagen membranes, with no molecular order, have already been used for several purposes, even in industry. Two alternative methods (patent Nº253249 of 1999 and AR048387 of 2006) of procedure to obtain soluble collagen and then the ordered membranes are presented. These membranes were characterized by measuring several physicochemical properties. UV and IR spectra are presented. They reveal a high purity degree of the material. Electronic microscopy measurements and interferometric experiments show a high level of order in the obtained membranes. Measurements of Ts (shrinkage temperature) and density are also presented. Permeability of the membranes for rifamycin, ascorbic acid and NaCl were measured at 37ºC and the results are presented.