CEQUINOR   05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Bioactivity of a Vanadyl(IV) Complex with a OOO-Donor Group on Osteoblast-Like Cells in Culture
Autor/es:
J RIVADENEIRA; D.BARRIO; L BRUZZONE; ENRIQUE JOSE BARAN; ETCHEVERRY, SB
Lugar:
San Francisco
Reunión:
Congreso; 5th. International Symposium on Chemistry and Biological Chemistry of Vanadium; 2006
Institución organizadora:
American Chemical Society
Resumen:
      The vanadyl(IV) complex [VO(oda)(H2O)2] (oda: oxodiacetate, O(CH2COO-)2) displayed antiapoptotic properties in some syustems. Herein, we report its bioactivity in two osteoblast cell lines (MC3T3E1 and UMR106). Cell proliferation was inhibited in both cell lines. Alkaline phosphatase specific activity and collagen production, two osteoblast differentiation markers, were also inhibited in UMR106 osteoblasts. Moreover, the complex caused morphological transformations and cytoskeleton reorganization of actin fibers. In UMR106 cells it generated oxidative stress and also enhances ERK phosphorilation in a concentration dependent manner.  
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