Oxovanadium(IV) Complexes with Flavonoids. Potential Antitumoral Actions

LEÓN I.E, MUGLIA C.I , DI VIRGILIO A.L, BARRIO D.A , NASO L.G, WILLIAM P.A.M, ETCHEVERRY S.B

Washington

Simposio; V8 8th International vanadium symposium Chemistry, Biological chemistry and toxicology; 2012

The family of polyphenolic flavonoids presents estrogenic, antiallergenic, antiviral, antiinflammatory, vasodilating and antitumoral effects1. Their pharmacological activity depends on the chemical structure. In particular, Chrysin (5,7-dihydroxy-2-phenyl-4H-chromen-4-one) and Silibinin (3,5,7-trihydroxy-2-[3-(S)-(4-hydroxy-3-methoxyphenyl)-2-(S)-(hydroxymethyl)-2,3-dihydro-1,4-enzodioxin-6-yl]chroman-4-one) are interesting members of this family, with potent antiproliferative effects against various malignant cells2. Bioavailability of these substances is improved by complexation with organic compounds3 or by metal coordination. Oxovanadium(IV) compounds show interesting pharmacological activity mainly as insulin enhancers, osteogenic and antitumoral agents4. As part of a project devoted to determine the antitumoral properties of oxovanadium(IV) complexes with flavonoids, we have investigated the cytotoxicity and genotoxicity of a vanadyl(IV) complex with Chrysin5 in a human derived osteosarcoma cell line (MG-63), and compare its inhibitory effects with that of the Silibinin derivative6. [VO(Chrysin)2EtOH]2 caused inhibition of the proliferation (70% vs basal) from 25 μM p