Plenary Lecture: Oxovanadium(IV) Complexes with Flavonoids. Potential Antitumoral Actions.

LEÓN IEÓN, IGNACIO ESTEBAN; MUGLIA, CECILIA ISABEL; DI VIRGILIO, ANA LAURA; BARRIO, DANIEL ALEJANDRO; NASO, LUCIANA; WILLIAMS, PATRICIA; ETCHEVERRY, SUSANA BEATRIZ

Washington DC

Simposio; 8th International Vanadium Symposium; 2012

American Chemical Society

The family of polyphenolic flavonoids presents estrogenic, antiallergenic, antiviral, antiinflammatory, vasodilating and antitumoral effects1. Their pharmacological activity depends on the chemical structure. In particular, Chrysin (5,7-dihydroxy-2-phenyl-4H-chromen-4-one) and Silibinin (3,5,7-trihydroxy-2-[3-(S)-(4-hydroxy-3-methoxyphenyl)-2-(S)-(hydroxymethyl)-2,3-dihydro-1,4-enzodioxin-6-yl]chroman-4-one) are interesting members of this family, with potent antiproliferative effects against various malignant cells2. Bioavailability of these substances is improved by complexation with organic compounds3 or by metal coordination. Oxovanadium(IV) compounds show interesting pharmacological activity mainly as insulin enhancers, osteogenic and antitumoral agents4. As part of a project devoted to determine the antitumoral properties of oxovanadium(IV) complexes with flavonoids, we have investigated the cytotoxicity and genotoxicity of a vanadyl(IV) complex with Chrysin5 in a human derived osteosarcoma cell line (MG-63), and compare its inhibitory effects with that of the Silibinin derivative6. [VO(Chrysin)2EtOH]2 caused inhibition of the proliferation (70% vs basal) from 25 μM p