Relationship between the biological behavior in two osteoblast cell lines with the radical scavenger activity of a new vanadyl(iv) complex with silibinin. Comparison with other VO-Flavonoid compounds.

P. A. M. W ILLIAMS; L. NASO; E. G. FERRER; LEZAMA, L.; ROJO, T.; ETCHEVERRY, S.B.

Tucson, Arizona

Conferencia; BioMetals Conference 2010.; 2010

Natural flavonoids have biological, pharmacological, and medicinal properties. They prevent a wide variety of diseases, which involve free radical-mediated damage in pathologically generating processes due to their antioxidant activity. In addition, their structure-activity relationship is well established. Among them, the extract of the flavolignan silibinin obtained form blessed milk thistle is used in medicine in cases of liver diseases. In addition, several vanadium compounds show potential pharmacological activity mainly as insulin mimics, antitumoral and osteogenic agents. The development of new vanadium derivatives with organic ligands to improve their biological behavior is of great interest. In this communication, the synthesis and characterization of the vanadyl-silibinin complex and the determination of the possible improvement of the antioxidant and antitumoral properties of the flavonoid are reported. The complex Na2[VO(silibinin)2].6H2O, VOsil, was obtained and the characterization was performed by elemental and thermogravimetric analysis, UV-vis, diffuse reflectance, EPR and FTIR spectroscopies. The radical scavenger activities of VOsil for superoxide, DPPH, ABTS and OH were greatly improved with respect to silibinin. The antitumoral and antioxidant properties were discussed and compared with previous results obtained in our laboratory for vanadyl(IV) complexes of quercetin, hesperidin, and chrysin.