Chronic treatment with Zn-Telmisartan improves cardiac function and the protective renin-angiotensin-system axis in ovariectomized spontaneously hypertensive rats.

PEREZ, NG; SILVA, MG; DE GIUSTI V.; MARTINEZ, V; VELEZ RUEDA OMAR; GIRONACCI, MM; DIAZ, RG; LOFEUDO JUAN MANUEL; WILLIAMS, PAM

Buenos Aires

Encuentro; Congreso conjunto Sociedad Argentina de Fisiología (SAFIS)/ Asociación Latino Americana de Ciencias Fisiológicas (ALACF); 2021

Argentinean Physiological Society and the Latin American Association of Physiological Sciences

cardiovascular diseases in menopausal women. We have previously modified the structure of the AngII receptor blocker telmisartan(Telm) with Zinc (ZnTelm), demonstrating higher drug effectiveness. In this work, we examined whether chronic ZnTelm treatment is abetter alternative to prevent cardiovascular damage during menopause than Telm alone. We used 16-week-old spontaneouslyhypertensive rats (SHR) which were sham-operated or bilateral ovariectomized (OVX-SHR). OVX-SHR rats were randomly divided into3 groups: non-treated (control), treated with Telm or ZnTelm (10 or 11 mg/kg/day, respectively, through drinking water for 8 weeks).Results (n=6 per group) were analyzed by ANOVA. * p