A Theoretical Study of a Family of 2-benzyl-3-methylquinoxaline-1,4-di-N-oxide Derivatives

E. VICENTE; P.R. DUCHOWICZ; M.G. VITALE; S. PÉREZ-SILANES; I. ALDANA; E.A. CASTRO; R. PIS DIEZ; A. MONGE

Simposio; XXI International Symposium on Medicinal Chemistry; 2010

The quinoxaline derivatives are a class of compounds that showvery interesting biological properties (antibacterial, antiviral,anticancer, antifungal, antihelmintic, and insecticidal). The oxidationof both nitrogens of this heterocyclic system, needed forobtaining quinoxaline 1,4-di-N-oxide derivatives, greatly increasesthe number of biological properties [1]. In fact, recent studieshave demonstrated that quinoxaline 1,4-di-N-oxides areendowed with antimycobacterial, antiprotozoal, and anticandidaactivities as well as mutagenic properties, depending on specificchemical features [1].