CEQUINOR   05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
capítulos de libros
Título:
OXOVANADIUM(IV) COMPLEXES WITH NON STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDs): PHARMACOLOGICAL RELEVANCE
Autor/es:
WILLIAMS PAM; ETCHEVERRY SB
Libro:
Vanadium Biochemistry
Editorial:
Research Signpost
Referencias:
Lugar: Trivandrum-695 023, Kerala, India; Año: 2007; p. 1 - 25
Resumen:
Abstract
Non steroidal anti-inflammatory drugs (NSAIDs) are a
group of substances of different chemical structures, even though most of them
are organic acids. The main pharmaceutical uses of these drugs are based on
their anti-inflammatory effects. Several diseases, such as cancer, also show an
inflammatory component and NSAIDs have also been used in the treatment of this
disease. NSAIDs inhibited the cyclooxygenase enzymes, specially COX-2,
chemotaxis, and the generation of free radical species. They also regulate the
cellular growth in different culture systems and caused apoptosis induction.
NSAIDs have been proven to be useful for the management of colon rectal
carcinoma and also bone tumors both primary and metastasis, in different animal
models. On the other hand, vanadium and its compounds exert promising
antitumoral actions on in vivo and in vitro models. The main involved
mechanisms seem to be the inhibition of protein tyrosine phosphatases and
stimulation of protein tyrosine kinases. In our laboratory we have synthesized
and characterized selected NSAIDs and vanadyl(IV) complexes. Their biological
effects were tested on two osteoblast like cells in culture, a normal cell line
(MC3T3E1) and a tumoral one (UMR106). Two of these compounds, the complexes
with Aspirin (VOAspi) and Naproxen (NapVO) displayed interesting antitumoral
properties in the osteoblasts in culture and merit further investigation to
evaluate their application in the treatment of cancer.