Vanadium and bone. Relevance of vanadium compounds in bone cells.

SUSANA B. ETCHEVERRY; DANIEL A. BARRIO.

Vanadium: The versatile element

Año: 2007; p. 204 - 216

Bone is one of the main tissues for vanadium storage in vertebrates. Vanadium compounds exert interesting biological effects as well as potential pharmacological actions. Herein we review the bioactivity of vanadium with emphasis in results obtained in bone related cells in culture. Vanadium compounds behaved as antitumoral agents, as growth factor mimetic compounds and as osteogenic drugs. We report for the first time, the effects of a complex of vanadyl(IV) cation with Trehalose on long-term cultures of non transformed osteoblasts. The complex induces cell proliferation, glucose consumption, osteoblast differentiation and the mineralization of the extracellular matrix