CEQUINOR   05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
artículos
Título:
Design of novel iron compounds as potential therapeutic agents against Tuberculosis
Autor/es:
M.B.TARALLO; A.MONGE; C.URQUIOLA,; B.PARAJÓN-COSTA; R.R.RIBEIRO; A.J.COSTA-FILHO; R. MERCADER; F.R.PAVAN; C.Q.F. LEITE; M.H.TORRE; D.GAMBINO
Revista:
JOURNAL OF INORGANIC BIOCHEMISTRY
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Año: 2010 vol. 104 p. 1164 - 1170
ISSN:
0162-0134
Resumen:
In the search for new
therapeutic tools against Tuberculosis two novel iron complexes, [Fe(L-H)3], with 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives (L) as ligands, were synthesized, characterized by a combination of
techniques, and in vitro evaluated. Results
were compared with those previously reported for two analogous iron complexes
of other ligands of the same family of quinoxaline derivatives. In addition, the
complexes were studied by cyclic voltammetry and electronic paramagnetic
resonance (EPR) spectroscopy. Cyclic
voltammograms of the iron compounds showed several cathodic processes which
were attributed to the reduction of the metal center (Fe3+/Fe2+)
and the coordinated ligand. These EPR signals were
characteristic of magnetically isolated high-spin Fe(III) in a rhombic
environment and arise from transitions between mS= ±
1/2 (geff~9) or mS= ±
3/2 (geff~4.3) states. Mössbauer experiments showed
hyperfine parameters that are typical of high spin Fe(III) ions in a not too distorted
environment. The novel complexes showed in vitro growth inhibitory activity on Mycobacterium tuberculosis H37Rv
(ATCC 27294), together with very low unspecific
cytotoxicity on eucariotic cells (cultured murine cell line J774). Both complexes showed higher inhibitory effects on M. tuberculosis than the second-line
therapeutic drugs.