CEQUINOR   05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
artículos
Título:
Synthesis, molecular structure and physicochemical properties of bis(3’-azido-3’-deoxythymidin-5’-yl) carbonate
Autor/es:
MÓNICA A. RAVIOLO, PATRICIA A.M. WILLIAMS, SUSANA B. ETCHEVERRY, OSCAR E. PIRO, EDUARDO E. CASTELLANO, MARIA S. GUALDESI, MARGARITA C. BRIÑÓN
Revista:
JOURNAL OF MOLECULAR STRUCTURE THEOCHEM
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2010 vol. 970 p. 59 - 59
ISSN:
0166-1280
Resumen:
30-Azido-30-deoxythymidine (zidovudine, AZT), a synthetic analog of natural nucleoside thymidine, has been used extensively in AIDS treatments. We report here the synthesis, X-ray crystal and molecular structure, NMR, IR and Raman spectra and the thermal behavior of a novel carbonate of AZT [(AZT–O)2C=O], prepared by the reaction of zidovudine with carbonyldiimidazole. The carbonate compound,C21H24N10O9, crystallizes in the tetragonal space group P41212 with a = b = 15.284(1), c = 21.695(1) Å, and Z = 8 molecules per unit cell. It consists of two AZT moieties of closely related conformations which are bridged by a carbonyl group to adopt a folded Z-like shape.