Physicochemical characterization of Cu(II) complexes with SOD-like activity, theoretical studies and biological assays

GONZÁLEZ-BARÓ, ANA C; PIS-DIEZ, REINALDO; FRANCA, CARLOS A.; TORRE, MARÍA H.; PARAJÓN-COSTA, BEATRIZ S.

POLYHEDRON

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2009

0277-5387

The mononuclear Cu(II) complex, [Cu(o-Va)2(H2O)2] (o-HVa = o-vanillin, 2-hydroxy-3-methoxybenzaldehyde)has been synthesized and characterized by elemental analyses, FTIR, FT-Raman, and electronicspectroscopies and compared with the results obtained for the free ligand. The optimized geometry,the harmonic vibrational frequencies and the electronic transitions of the complex and the ligand werecalculated using methods based on the density functional theory. Antimicrobial activity against Escherichiacoli and Staphylococcus aureus and SOD-mimic activities of the complex were studied and comparedwith the analogous copper complex with vanillin, [Cu(Va)2(H2O)2]. Stability of the compounds in theessayed solution and with time was determined by means of conductimetric measurements. Their redoxbehavior was studied by cyclic voltammetry and was compared with that observed for the ligands. Thecomplexes undergo two main reductions and one oxidation processes involving the metal center and thecoordinated ligand, respectively