CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
Copper(II) complexes of methimazole, an anti Graves disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
NORA M. URQUIZA ,SILVIA G. MANCA, MARÍA A. MOYANO, RAQUEL ARRIETA DELLMANS, LUIS LEZAMA, TEÓFILO ROJO, LUCIANA G. NASO, PATRICIA A. M. WILLIAMS, EVELINA G. FERRER
Lugar: Alemania; Año: 2010 vol. 23 p. 225 - 225
Abstract Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Graves disease. Two new copper(II) complexes of this drug:[Cu(MeimzH)2(NO3)2].0.5H2O and [Cu(MeimzH)2(H2O)2](NO3)2.H2O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.