CEQUINOR   05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
artículos
Título:
Copper(II) complexes of methimazole, an anti Grave’s disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
Autor/es:
NORA M. URQUIZA ,SILVIA G. MANCA, MARÍA A. MOYANO, RAQUEL ARRIETA DELLMANS, LUIS LEZAMA, TEÓFILO ROJO, LUCIANA G. NASO, PATRICIA A. M. WILLIAMS, EVELINA G. FERRER
Revista:
BIOMETALS
Editorial:
SPRINGER
Referencias:
Lugar: Alemania; Año: 2010 vol. 23 p. 225 - 225
ISSN:
0966-0844
Resumen:
Abstract Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug:[Cu(MeimzH)2(NO3)2].0.5H2O and [Cu(MeimzH)2(H2O)2](NO3)2.H2O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.