Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent

CARLOS H.LAINO; OSCAR E.PIRO; GRACIELA E. ESCUDERO; GUSTAVO A.ECHEVERRIA; NANCY MARTINI; EVELINA G. FERRER; PATRICIA A. M. WILLIAMS

Annals of Medicinal Chemistry and Research

SciMedCentral

Lugar: California; Año: 2017 vol. 3 p. 1 - 11

2378-9336

A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefitsof sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized asalt formulation (SerH2)2+[ZnCl4]2- (C34H36N2Cl8Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. Itcrystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 moleculesper unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertralinehydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in theassimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº20150103320) in Argentine country.