CEQUINOR 05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
artículos
Título:
Copper(II) complexes of Methimazole, an anti Grave´s disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor
Autor/es:
URQUIZA, N.; MANCA, S. G.; MARÍA ALEJANDRA MOYANO; RAQUEL ARRIETA DELLMANS; LEZAMA, L.; TEÓFILO ROJO; L. NASO; P. A. M. W ILLIAMS; E. G. FERRER
Revista:
BIOMETALS
Editorial:
SPRINGER
Referencias:
Año: 2009 vol. 23 p. 255 - 264
ISSN:
0966-0844
Resumen:
Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Graves disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)2(NO3)2].0.5H2O and [Cu (MeimzH)2 (H2O)2](NO3)2H2O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated
