Biological activities of Zn(II)-S-methyl-cysteine complex as antiradical, inhibitor of acid phosphatase enzyme and in vivo antidepressant effects

NACY MARTINI; NAHUEL R. MARESCA; WILLIAMS PATRICIA A.M.; ESCUDERO GRACIELA; NADIR JORI; LUCIANA G. NASO; KHALIL JORI; LAINO CARLOS H; FERRER EVELINA G.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

TAYLOR & FRANCIS LTD

Lugar: Londres; Año: 2016 vol. 31 p. 1625 - 1631

1475-6366

The antidepressant effect of simple Zn(II) salts has been proved in several animal models ofdepression. In this study, a coordination metal complex of Zn(II) having a sulfur containingligand is tested as antidepressant for the first time. Forced swimming test method on maleWistar rats shows a decrease in the immobility and an increase in the swimming behavior aftertreatment with [Zn(S-Met)2] (S-Met¼S-methyl-L-cysteine) being more effective and remarkablethan ZnCl2. The thiobarbituric acid and the pyranine consumption (hydroxyl and peroxylradicals, respectively) methods were applied to evaluate the antioxidant activity of S-Met and[Zn(S-Met)2] showing evidence of attenuation of hydroxyl but not peroxyl radicals activities. UVvisstudies on the inhibition of acid phosphatase enzyme (AcP) demonstrated that S-methyl-Lcysteinedid not produce any effect but, in contrast, [Zn(S-Met)2] complex behaved as amoderate inhibitor. Finally, bioavailability studies were performed by fluorescence spectroscopydenoting the ability of the albumin to transport the complex.