CEQUINOR 05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
artículos
Título:
Heteroleptic complexes of antifungal drugs with the silver ion
Autor/es:
C. GUILDORI; M. VEGA; M. RAIMONDI; B. TOPLIKAR; L. SVETAZ; N. MOSCONI; WILLIAMS PATRICIA A.M.; M. RIZZOTTO
Revista:
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
Editorial:
JOHN WILEY & SONS LTD
Referencias:
Lugar: LOndres; Año: 2016 vol. 29 p. 656 - 664
ISSN:
0894-3230
Resumen:
ABSTRACT: In spite of a large number of antibiotics and chemotherapeutics available for medicaluse, the emergence of old and new antibiotic resistance in the last decades revealed a substantialmedical need for new classes of antimicrobial agents. In this paper we report the synthesis,characterization by elemental analysis, FTIR and NMR spectroscopies and antifungal properties oftwo heteroleptic complexes of albendazole (albz) with Ag(I), using KSCN and o-phenanthroline(phen) as the second ligand respectively. Both complexes showed a moderate antifungal activitywith all the assayed fungi, mainly Candida albicans and C. tropicalis, that showed no activityagainst albendazole.
