CEQUINOR   05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
artículos
Título:
Cytotoxicity Action of an Oxidovanadium(IV)-DPPZ Complex on MG 63 Osteosarcoma Cell Line
Autor/es:
IGNACIO E. LEON; ETCHEVERRY, SUSANA B; BARAN, ENRIQUE JOSÉ
Revista:
Bio Technology, An Indian Journal
Editorial:
TSI-Journals
Referencias:
Lugar: New Delhi; Año: 2015 vol. 11 p. 465 - 465
ISSN:
0974-7435
Resumen:
The cytotoxicity activity of the recently reported[VO(H2O)2(SO4)dppz]2H2O complex (dppz = dipyrido[3,2-a:2?,3?-c]phenazine) on MG-63 human osteosarcoma cell line was investigated.It was found that it caused a concentration related inhibitory effect in theconcentration range between 5 and 25 Mand diminished the cell viabilityca. 40% in the range from 25 to 100 ìM, without dose/response effectsin this range. These biological effects are, in general, similar to thosepreviously reported for the related [VO(ODA)dppz]3H2O (ODA= dianionof oxodiacetic acid) and [VO(ODA)(phen)]1.5H2O (phen = ophenanthroline)complexes. The importance of the presence of DNAintercalatingligands in these complexes is emphasized.