CEQUINOR   05415
CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
artículos
Título:
Spectroscopic Characterization of a VO(2+) Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture
Autor/es:
RIVADENEIRA J, BARRIO DA, ETCHEVERRY SB, BARAN EJ
Revista:
Biological Trace Element Research
Editorial:
Human Press Inc.
Referencias:
Año: 2007 vol. 118 p. 159 - 159
ISSN:
0163-4984
Resumen:
     The oxovanadium (IV) complex of oxodiacetic acid (H2oda) of stoichiometry [VO(oda)(H2O)2], which presents an unprecedented tridentate OOO coordination, was thoroughly characterized by infrared, Raman , electronic and electron paramegnetic resonance spectroscopies. The biological activity of the complex on the cell proliferation and differentiation was tested on osteoblast-like cells (MC3T3E1 osteblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture.  The effect of the complex in cell differentiation was tested through the specfic activity of alkaline phosphatase of the UMR106 cells because they expressed a high activity of this enzyme. 
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