CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
Spectroscopic Characterization of a VO(2+) Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture
RIVADENEIRA J, BARRIO DA, ETCHEVERRY SB, BARAN EJ
Biological Trace Element Research
Human Press Inc.
Año: 2007 vol. 118 p. 159 - 159
The oxovanadium (IV) complex of oxodiacetic acid (H2oda) of stoichiometry [VO(oda)(H2O)2], which presents an unprecedented tridentate OOO coordination, was thoroughly characterized by infrared, Raman , electronic and electron paramegnetic resonance spectroscopies. The biological activity of the complex on the cell proliferation and differentiation was tested on osteoblast-like cells (MC3T3E1 osteblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The effect of the complex in cell differentiation was tested through the specfic activity of alkaline phosphatase of the UMR106 cells because they expressed a high activity of this enzyme.