CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
Metal complexes of the antihypertensive drugs that inhibit the renin-angiotensin system
Current Trends in Medicinal Chemistry
Año: 2014 vol. 7 p. 97 - 97
Hypertension affects nearly 1/3 of adult populationworldwide. Several classes of medications areavailable to lower blood pressure including diuretics,β-blockers, calcium channel blockers (CCB) andthe inhibitors of the renin-angiotensin system(RAS) such as renin inhibitors, angiotensin convertingenzyme (ACE) inhibitors and angiotensin II receptorblockers (ARB). Biometals are metal ions importantfor the vital functions of the living organisms andare able to chelate the administered medicationsand modify their structures. A great number ofmetal complexes of ACE inhibitors have beenstudied. Considering the recent development ofthe ARBs by rational drug design methods, itis important also to study metal complexes ofthe sartans family. The aim of this review is todescribe the metal complexes of the ACE and ARBfamilies and some of their biological properties.