CENTRO DE QUIMICA INORGANICA "DR. PEDRO J. AYMONINO"
Unidad Ejecutora - UE
Synthesis, Characterization, and Biological Activity of Oxovanadium(IV) Complexes with Polyalcohols
WILLIAMS, PAM; ETCHEVERRY, SB; D.BARRIO; ENRIQUE JOSE BARAN
Año: 2006 vol. 341 p. 717 - 717
Oxovanadium(IV) complexes of the polyalcohols sorbitol, galactitol, and mannitol, of stoichiometry Na2[VO(L)2].nH2O, were obtained from aqueous alkaline solutions. They were characterized by elemental analysis, IR and UV-vis spectroscopies, thermoanalytical (thermogravimetric and differential thermal analysis) data and magnetic susceptibility measurements. The biological activities of the complexes on the proliferation, differentiation and glucose consumptios was tested on osteoblast-like cells (MC3T3E osteoblast mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The three complexes exerted biphasic effect on cell proliferation, being slight stimulating agents at low concentrations and inhibitory in the range of 25-100 microM. All the complexes inhibited cell differentiation in tumor osteoblasts. Their effect on glucose consumption were also discussed. The free ligands did not show any effect on the studied biological parameters.